The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia

被引：85

作者：

Munro-Davies, LE

Winter, J

Aziz, TZ

Stein, JF

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

[2] Univ Oxford, Radcliffe Infirm, Dept Neurosurg, Oxford OX2 6HE, England

来源：

EXPERIMENTAL BRAIN RESEARCH | 1999年 / 129卷 / 04期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease (PD); pedunculopontine nucleus (PPN); akinesia; kainic acid (KA);

D O I：

10.1007/s002210050921

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The akinesia of Parkinsonism is relieved by pallidotomy and subthalamic nucleotomy, but not by thalamotomy. Therefore, this disabling symptom probably depends upon connections other than the pallidalthalamocortical tracts, possibly efferents of the medial pallidum descending to the upper brainstem. We have previously demonstrated akinesia in the normal monkey following radiofrequency lesioning in the region of the pedunculopontine nucleus (PPN), one of the primary targets for descending pallidal outflow. Here, we confirm that selectively destroying neurones in the PPN area, whilst sparing fibres of passage, results in an akinetic state in normal macaques.

引用

收藏

页码：511 / 517

页数：7

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