Time trends in warfarin-associated hemorrhage

被引：49

作者：

Kucher, N

Castellanos, LR

Quiroz, R

Koo, S

Fanikos, J

Goldhaber, SZ

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiovasc,Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pharm, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 94卷 / 03期

关键词：

D O I：

10.1016/j.amjcard.2004.04.050

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The annual incidence of warfarin-related bleeding at Brigham and Women's Hospital increased from 0.97/1,000 patient admissions in the first time period (January 1995 to October 1998) to 1.19/1,000 patient admissions in the second time period (November 1998 to August 2002) of this study. The proportion of patients with major and intracranial bleeding increased from 20.2% and 1.9%, respectively, in the first time period, to 33.3% and 7.8%, respectively, in the second. (C)2004 by Excerpta Medical, Inc.

引用

收藏

页码：403 / 406

页数：4

相关论文

共 20 条

[1]

BEEST FJP, 2001, CLIN PHARMACOL THER, V69, P451

[2] Hemorrhagic events during therapy with recombinant tissue plasminogen activator, heparin, and aspirin for unstable angina (Thrombolysis in myocardial ischemia, phase IIIB trial) [J].

Bovill, EG ;

Tracy, RP ;

Knatterud, GL ;

Stone, PH ;

Nasmith, J ;

Gore, JM ;

Thompson, BW ;

Tofler, GH ;

Kleiman, NS ;

Cannon, C ;

Braunwald, E .

AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (04) :391-396

[3] RISK-FACTORS FOR COMPLICATIONS OF CHRONIC ANTICOAGULATION - A MULTICENTER STUDY [J].

FIHN, SD ;

MCDONELL, M ;

MARTIN, D ;

HENIKOFF, J ;

VERMES, D ;

KENT, D ;

WHITE, RH .

ANNALS OF INTERNAL MEDICINE, 1993, 118 (07) :511-520

[4] Oral anticoagulants: Mechanism of action, clinical effectiveness, and optimal therapeutic range [J].

Hirsh, J ;

Dalen, JE ;

Anderson, DR ;

Poller, L ;

Bussey, H ;

Ansell, J ;

Deykin, D .

CHEST, 2001, 119 (01) :8S-21S

[5] Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation [J].

Hylck, EM ;

Chang, YC ;

Skates, SJ ;

Hughes, RA ;

Singer, DE .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (11) :1612-1617

[6] Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation [J].

Hylek, EM ;

Go, AS ;

Chang, YC ;

Jensvold, NG ;

Henault, LE ;

Selby, JV ;

Singer, DE .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (11) :1019-1026

[7] RISK-FACTORS FAR INTRACRANIAL HEMORRHAGE IN OUTPATIENTS TAKING WARFARIN [J].

HYLEK, EM ;

SINGER, DE .

ANNALS OF INTERNAL MEDICINE, 1994, 120 (11) :897-902

[8] An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation [J].

Hylek, EM ;

Skates, SJ ;

Sheehan, MA ;

Singer, DE .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (08) :540-546

[9] Acetaminophen and other risk factors for excessive warfarin anticoagulation [J].

Hylek, EM ;

Heiman, H ;

Skates, SJ ;

Sheehan, MA ;

Singer, DE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (09) :657-662

[10]

KOUDSTAAL PJ, 1995, NEW ENGL J MED, V333, P5