Synthesis and antituberculosis activity of new N-phenyl-N′-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas

被引：121

作者：

Karakus, S ^{[1
]}

Rollas, S ^{[1
]}

机构：

[1] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-81010 Istanbul, Turkey

来源：

FARMACO | 2002年 / 57卷 / 07期

关键词：

1,3,4-thiadiazole; thiourea; antituberculosis activity;

D O I：

10.1016/S0014-827X(02)01252-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, eight original N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea, derivatives were synthesized and tested for antituberculosis activity. Antituberculosis activities of the synthesized compounds were screened in vitro using BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 mug/ml. The highest inhibition observed with the synthesized compounds is 67% for N-phenyl-N'-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：577 / 581

页数：5

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