Activity-dependent regulation of genes implicated in X-linked non-specific mental retardation

被引：22

作者：

Boda, B ^{[1
]}

Mas, C ^{[1
]}

Muller, D ^{[1
]}

机构：

[1] Ctr Med Univ Geneva, Dept Morphol, CH-1211 Geneva 4, Switzerland

来源：

NEUROSCIENCE | 2002年 / 114卷 / 01期

关键词：

long-term potentiation; hippocampus; mental retardation; synaptic plasticity; kainate induced seizures; real-time quantitative PCR;

D O I：

10.1016/S0306-4522(02)00218-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

X-linked forms of non-specific mental retardation are complex disorders, for which mutations in several genes have recently been identified. These include OPHN1, GDI1, PAK3, IL1RAPL, TM4SF2, FMR2 and RSK2. To investigate the mechanisms through which alterations of these gene products could result in cognitive impairment, we analyzed their expression using quantitative PCR technique in two in vitro models of activity-dependent gene regulation: kainate-induced seizures and long-term synaptic potentiation (LTP). We found that the level of expression of four genes, PAK3, IL1RAPL, RSK2 and TM4SF2, was significantly up-regulated following kainate treatment. Furthermore we observed a significant increase in mRNA levels of PAK3 and IL1RAPL following LTP induction. These results suggest a possible role for these four genes in activity-dependent brain plasticity. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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页码：13 / 17

页数：5

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