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Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes

被引：53
作者：
Ribatti, D
Polimeno, G
Vacca, A
Marzullo, A
Crivellato, E
Nico, B
Lucarelli, G
Dammacco, F
机构：
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, Policlin, I-70124 Bari, Italy
[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy
[3] Univ Bari, Sch Med, Inst Pathol, I-70124 Bari, Italy
[4] Osped Gen F Miulli, Acquaviva Delle Fonti, Italy
[5] Univ Udine, Sch Med, Dept Med & Morphol Res, Sect Anat, I-33100 Udine, Italy
来源：
LEUKEMIA | 2002年 / 16卷 / 09期
关键词：
angiogenesis; mast cells; myelodysplastic syndrome; tryptase; tumor progression;
D O I：
10.1038/sj.leu.2402586
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and M expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.
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收藏
页码：1680 / 1684
页数：5
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