Regulation of chromatin structure by histone H3S10 phosphorylation

被引：120

作者：

Johansen, Kristen M. ^{[1
]}

Johansen, Jorgen ^{[1
]}

机构：

[1] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA

来源：

CHROMOSOME RESEARCH | 2006年 / 14卷 / 04期

关键词：

chromatin; Drosophila; histone code; histone H3S10 phosphorylation;

D O I：

10.1007/s10577-006-1063-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epigenetic phospho-serine 10 modification of histone H3 has been a puzzle due to its association with two apparently opposed chromatin states. It is found at elevated levels on the highly condensed, transcriptionally inactive mitotic chromosomes yet is also correlated with the more extended chromatin configuration of active genes, euchromatic interband regions, and activated heat shock puffs of Drosophila polytene chromosomes. In addition, phosphorylation of histone H3S10 is up-regulated on the hypertranscribed male X chromosome. Here we review the cellular effects of histone H3S10 phosphorylation and discuss a model for its involvement in regulating chromatin organization and heterochromatization that would be applicable to both interphase and mitotic chromosomes.

引用

页码：393 / 404

页数：12

共 86 条

[1] Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation [J].

Adams, RR ;

Maiato, H ;

Earnshaw, WC ;

Carmena, M .

JOURNAL OF CELL BIOLOGY, 2001, 153 (04) :865-879

[2] Deciphering the transcriptional histone acetylation code for a human gene [J].

Agalioti, T ;

Chen, GY ;

Thanos, D .

CELL, 2002, 111 (03) :381-392

[3] Dosage compensation: an intertwined world of RNA and chromatin remodelling [J].

Akhtar, A .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (02) :161-169

[4] A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression [J].

Anest, V ;

Hanson, JL ;

Cogswell, PC ;

Steinbrecher, KA ;

Strahl, BD ;

Baldwin, AS .

NATURE, 2003, 423 (6940) :659-663

[5] PATTERNS OF PUFFING ACTIVITY IN SALIVARY GLAND CHROMOSOMES OF DROSOPHILA .5. RESPONSES TO ENVIRONMENTAL TREATMENTS [J].

ASHBURNER, M .

CHROMOSOMA, 1970, 31 (03) :356-+

[6] MITOGEN-STIMULATED PHOSPHORYLATION OF HISTONE H3 IS TARGETED TO A SMALL HYPERACETYLATION-SENSITIVE FRACTION [J].

BARRATT, MJ ;

HAZZALIN, CA ;

CANO, E ;

MAHADEVAN, LC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4781-4785

[7] ATP-dependent nucleosomere modeling [J].

Becker, PB ;

Hörz, W .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :247-273

[8]

BELOTE JM, 1980, GENETICS, V96, P165

[9] ACETYLATED HISTONE H4 ON THE MALE X-CHROMOSOME IS ASSOCIATED WITH DOSAGE COMPENSATION IN DROSOPHILA [J].

BONE, JR ;

LAVENDER, J ;

RICHMAN, R ;

PALMER, MJ ;

TURNER, BM ;

KURODA, MI .

GENES & DEVELOPMENT, 1994, 8 (01) :96-117

[10] Does looping and clustering in the nucleus regulate gene expression? [J].

Chambeyron, S ;

Bickmore, WA .

CURRENT OPINION IN CELL BIOLOGY, 2004, 16 (03) :256-262

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