Cancer gene detection using surface-enhanced Raman scattering (SERS)

被引：167

作者：

Vo-Dinh, T ^{[1
]}

Allain, LR ^{[1
]}

Stokes, DL ^{[1
]}

机构：

[1] Oak Ridge Natl Lab, Div Life Sci, Adv Monitoring Dev Grp, Oak Ridge, TN 37831 USA

来源：

JOURNAL OF RAMAN SPECTROSCOPY | 2002年 / 33卷 / 07期

关键词：

D O I：

10.1002/jrs.883

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

We describe the development of a surface-enhanced Raman scattering (SERS) method for cancer gene detection. The technology uses DNA gene probes based on SERS labels for gene detection. The detection method uses nanostructured metallic substrates as SERS-active platforms. The surface-enhanced Raman gene (SERGen) probes can be used to detect DNA targets via hybridization to DNA sequences complementary to these probes. The probes do not require the use of radioactive labels and have great potential to provide both sensitivity and selectivity. The usefulness of the SERGen approach and its applications in cancer gene diagnostics (e.g. BRCA1 breast cancer gene and BAX gene) is discussed. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：511 / 516

页数：6

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