A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients

被引：47

作者：

McMillan, DC ^{[1
]}

OGorman, P ^{[1
]}

Fearon, KCH ^{[1
]}

McArdle, CS ^{[1
]}

机构：

[1] UNIV EDINBURGH,ROYAL INFIRM,DEPT SURG,EDINBURGH EH3 9YW,MIDLOTHIAN,SCOTLAND

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 06期

关键词：

gastrointestinal cancer; weight loss; megestrol acetate; ibuprofen; acute-phase response;

D O I：

10.1038/bjc.1997.463

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study.

引用

页码：788 / 790

页数：3

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