The in-vitro activity of trovafloxacin and nine other antimicrobials against 413 anaerobic bacteria

The in-vitro activity of trovafloxacin and nine other antimicrobials was determined for 413 non copy anaerobic clinical isolates. Trovafloxacin was the most active quinolone tested with an MIC(90) of 0.5 mg/L against Gram-positive cocci (n = 75); MIC(90) of 4 mg/L against Gram-positive bacilli (n = 151); MIC(90) of 0.5 mg/L for Gram-negative cocci (n = 12) and MIC(90) of 1 mg/L for Gram-negative bacilli (n = 175). Overall the MIC(90) of trovafloxacin was 1 mg/L which was equivalent to co-amoxiclav and one dilution higher than that of imipenem. The other seven comparators, including clindamycin and metronidazole, had higher MIC(90) values than trovafloxacin. Trovafloxacin is likely to have clinically useful activity against anaerobes from human infection.