A genome-based strategy uncovers frequent BRAF mutations in melanoma

被引：115

作者：

Pollock, PM ^{[1
]}

Meltzer, PS ^{[1
]}

机构：

[1] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA

来源：

CANCER CELL | 2002年 / 2卷 / 01期

关键词：

D O I：

10.1016/S1535-6108(02)00089-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using a genome-scanning approach to search for oncogenes, a recent report identifies somatic mutations in the signaling gene BRAF that are particularly prevalent in melanoma.

引用

页码：5 / 7

页数：3

共 12 条

[1] Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
Ali, IU
Schriml, LM
Dean, M
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22): : 1922 - 1932
[2] Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
Buscà, R
Abbe, P
Mantoux, F
Aberdam, E
Peyssonnaux, C
Eychène, A
Ortonne, JP
Ballotti, R
[J]. EMBO JOURNAL, 2000, 19 (12) : 2900 - 2910
[3] Essential role for oncogenic Ras in tumour maintenance
Chin, L
Tam, A
Pomerantz, J
Wong, M
Holash, J
Bardeesy, N
Shen, Q
O'Hagan, R
Pantginis, J
Zhou, H
Horner, JW
Cordon-Cardo, C
Yancopoulos, GD
DePinho, RA
[J]. NATURE, 1999, 400 (6743) : 468 - 472
[4] Mutations of the BRAF gene in human cancer
Davies, H
Bignell, GR
Cox, C
Stephens, P
Edkins, S
Clegg, S
Teague, J
Woffendin, H
Garnett, MJ
Bottomley, W
Davis, N
Dicks, N
Ewing, R
Floyd, Y
Gray, K
Hall, S
Hawes, R
Hughes, J
Kosmidou, V
Menzies, A
Mould, C
Parker, A
Stevens, C
Watt, S
Hooper, S
Wilson, R
Jayatilake, H
Gusterson, BA
Cooper, C
Shipley, J
Hargrave, D
Pritchard-Jones, K
Maitland, N
Chenevix-Trench, G
Riggins, GJ
Bigner, DD
Palmieri, G
Cossu, A
Flanagan, A
Nicholson, A
Ho, JWC
Leung, SY
Yuen, ST
Weber, BL
Siegler, HF
Darrow, TL
Paterson, H
Marais, R
Marshall, CJ
Wooster, R
[J]. NATURE, 2002, 417 (6892) : 949 - 954
[5] Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma
Demunter, A
Stas, M
Degreef, H
De Wolf-Peeters, C
van den Oord, JJ
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (06) : 1483 - 1489
[6] GREENBLATT MS, 1994, CANCER RES, V54, P4855
[7] Modelling the molecular circuitry of cancer
Hahn, WC
Weinberg, RA
[J]. NATURE REVIEWS CANCER, 2002, 2 (05) : 331 - 341
[8] Herlyn M, 1996, AM J PATHOL, V149, P739
[9] Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes
Imokawa, G
Yada, Y
Kimura, M
[J]. BIOCHEMICAL JOURNAL, 1996, 314 : 305 - 312
[10] Neonatal sunburn and melanoma in mice - Severe sunburn in newborn, but not adult, mice is linked with melanoma in later life.
Noonan, FP
Recio, JA
Takayama, H
Duray, P
Anver, MR
Rush, WL
De Fabo, EC
Merlino, G
[J]. NATURE, 2001, 413 (6853) : 271 - 272

← 1 2 →