Biomarkers of premature atherosclerosis

被引：89

作者：

Kampoli, Anna-Maria ^{[1
]}

Tousoulis, Dirnitris ^{[1
]}

Antoniades, Charalambos ^{[1
]}

Siasos, Gerasimos ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Cardiol Dept 1, Hippokrat Hosp, GR-11527 Athens, Greece

来源：

TRENDS IN MOLECULAR MEDICINE | 2009年 / 15卷 / 07期

关键词：

CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE SYNDROME; CELL-ADHESION MOLECULE-1; NECROSIS-FACTOR-ALPHA; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; MYOCARDIAL-INFARCTION; RISK-FACTORS;

D O I：

10.1016/j.molmed.2009.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-reactive protein (CRP) is an acute phase protein and a biochemical marker with important prognostic value for cardiovascular events. Interleukins IL-1 and IL-6 are implicated in the pathogenesis of atherosclerosis and are associated with CRP. Apolipoproteins ApoA-I and ApoB are the main lipid metabolic markers implicated in the development and progression of atherosclerosis. Fibrinogen has also been proposed to be a major independent risk factor for cardiovascular events. Because premature atherosclerosis precedes the development of cardiovascular disease, identification of the associated biomarkers is of great importance. However, further studies will be needed to determine whether or not these markers are useful predictors of future cardiovascular events. Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis.

引用

页码：323 / 332

页数：10

共 83 条

[1] Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression [J].

Alp, NJ ;

Mussa, S ;

Khoo, J ;

Cai, SJ ;

Guzik, T ;

Jefferson, A ;

Goh, N ;

Rockett, KA ;

Channon, KM .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (05) :725-735

[2] Endothelium-dependent coronary vasomotion relates to the susceptibility of LDL to oxidation in humans [J].

Anderson, TJ ;

Meredith, IT ;

Charbonneau, F ;

Yeung, AC ;

Frei, B ;

Selwyn, AP ;

Ganz, P .

CIRCULATION, 1996, 93 (09) :1647-1650

[3] Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not, in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines [J].

Antoniades, Charalainbos ;

Tousoulis, Dimitris ;

Marinou, Kyriakoula ;

Vasiliadou, Carmen ;

Tentolouris, Costantinos ;

Bouras, George ;

Pitsavos, Christos ;

Stefanadis, Christodoulos .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 84 (04) :781-788

[4] Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study [J].

Ballantyne, CM ;

Hoogeveen, RC ;

Bang, H ;

Coresh, J ;

Folsom, AR ;

Heiss, G ;

Sharrett, AR .

CIRCULATION, 2004, 109 (07) :837-842

[5] Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B -: The Copenhagen city heart study [J].

Benn, Marianne ;

Nordestgaard, Borge G. ;

Jensen, Gorm Boje ;

Tybjærg-Hansen, Anne .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (03) :661-670

[6] Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review [J].

Benn, Marianne .

ATHEROSCLEROSIS, 2009, 206 (01) :17-30

[7] ATHEROSCLEROSIS - BASIC MECHANISMS - OXIDATION, INFLAMMATION, AND GENETICS [J].

BERLINER, JA ;

NAVAB, M ;

FOGELMAN, AM ;

FRANK, JS ;

DEMER, LL ;

EDWARDS, PA ;

WATSON, AD ;

LUSIS, AJ .

CIRCULATION, 1995, 91 (09) :2488-2496

[8] High-Sensitivity C-Reactive Protein Is Not Independently Associated With Peripheral Subclinical Atherosclerosis [J].

Bo, Mario ;

Corsinovi, Laura ;

Brescianini, Alessia ;

Sona, Alessandro ;

Astengo, Marco ;

Dumitrache, Raluca ;

Ferrio, Maria Federica ;

Pricop, Larisa ;

Fonte, Gianfranco .

ANGIOLOGY, 2009, 60 (01) :12-20

[9] Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study) [J].

Cesari, M ;

Penninx, BWJH ;

Newman, AB ;

Kritchevsky, SB ;

Nicklas, BJ ;

Sutton-Tyrrell, K ;

Tracy, RP ;

Rubin, SM ;

Harris, TB ;

Pahor, M .

AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (05) :522-528

[10] Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding [J].

Chamberlain, Janet ;

Francis, Sheila ;

Brookes, Zoe ;

Shaw, Gary ;

Graham, Delyth ;

Alp, Nicholas J. ;

Dower, Steven ;

Crossman, David C. .

PLOS ONE, 2009, 4 (04)

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