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A plethora of mechanisms in the HERG-related long QT syndrome -: Genetics meets electrophysiology

被引：44
作者：
Roden, DM
Balser, JR
机构：
[1] Vanderbilt Univ, Div Clin Pharmacol, Sch Med, Dept Med, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Dept Anesthesiol, Nashville, TN 37232 USA
来源：
CARDIOVASCULAR RESEARCH | 1999年 / 44卷 / 02期
关键词：
D O I：
10.1016/S0008-6363(99)00224-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：242 / 246
页数：5
相关论文
共 43 条
  • [1] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
    Abbott, GW
    Sesti, F
    Splawski, I
    Buck, ME
    Lehmann, WH
    Timothy, KW
    Keating, MT
    Goldstein, SAN
    [J]. CELL, 1999, 97 (02) : 175 - 187
  • [2] Bianchi L, 1998, CANCER RES, V58, P815
  • [3] Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action
    Busch, AE
    Eigenberger, B
    Jurkiewicz, NK
    Salata, JJ
    Pica, A
    Suessbrich, H
    Lang, F
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (01) : 23 - 30
  • [4] Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain
    Cabral, JHM
    Lee, A
    Cohen, SL
    Chait, BT
    Li, M
    Mackinnon, R
    [J]. CELL, 1998, 95 (05) : 649 - 655
  • [5] USE-DEPENDENT BLOCK AND USE-DEPENDENT UNBLOCK OF THE DELAYED RECTIFIER K+ CURRENT BY ALMOKALANT IN RABBIT VENTRICULAR MYOCYTES
    CARMELIET, E
    [J]. CIRCULATION RESEARCH, 1993, 73 (05) : 857 - 868
  • [6] Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
    Chen, J
    Zou, AR
    Splawski, I
    Keating, MT
    Sanguinetti, MC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (15) : 10113 - 10118
  • [7] A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT SYNDROME
    CURRAN, ME
    SPLAWSKI, I
    TIMOTHY, KW
    VINCENT, GM
    GREEN, ED
    KEATING, MT
    [J]. CELL, 1995, 80 (05) : 795 - 803
  • [8] Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval
    Drolet, B
    Khalifa, M
    Daleau, P
    Hamelin, BA
    Turgeon, J
    [J]. CIRCULATION, 1998, 97 (02) : 204 - 210
  • [9] Drolet B, 1999, J PHARMACOL EXP THER, V288, P1261
  • [10] Molecular determinants of dofetilide block of HERG K+ channels
    Ficker, E
    Jarolimek, W
    Kiehn, J
    Baumann, A
    Brown, AM
    [J]. CIRCULATION RESEARCH, 1998, 82 (03) : 386 - 395
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