Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation

被引：54

作者：

Görtz, B

Hayer, S

Redlich, K

Zwerina, J

Tohidast-Akrad, M

Tuerk, B

Hartmann, C

Kollias, G

Steiner, G

Smolen, JS

Schett, G

机构：

[1] Univ Vienna, Div Rheumatol, Dept Internal Med 3, A-1090 Vienna, Austria

[2] Ludwig Boltzmann Inst Rheumatol & Balneol, Vienna, Austria

[3] Res Inst Mol Pathol, A-1030 Vienna, Austria

[4] Alxander Fleming Biomed Sci Res Ctr, Genet Mol Lab, Inst Immunol, Vari, Greece

[5] Austrian Acad Sci, Ctr Mol Med, A-1010 Vienna, Austria

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 06期

关键词：

arthritis; bone erosion; bone marrow inflammation; osteoblasts; B-cells; bone morphogenetic proteins;

D O I：

10.1359/JBMR.040205

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Arthritis can destroy the cortical bone barrier and expose bone marrow to synovial tissue. This study examines bone marrow changes in arthritis and its effects on cortical bone remodeling. Bone marrow next to arthritic lesions exhibits B-lymphocyte-rich infiltrates, which express BMPs and stimulate endosteal bone formation. Thus, bone marrow actively participates in the arthritic process.

引用

页码：990 / 998

页数：9

共 26 条

[1]

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin [J].