Maximizing the impact of microphysiological systems with in vitro-in vivo translation

被引：56

作者：

Cirit, Murat ^{[1
]}

Stokes, Cynthia L. ^{[2
]}

机构：

[1] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] Stokes Consulting, Redwood City, CA USA

来源：

LAB ON A CHIP | 2018年 / 18卷 / 13期

关键词：

INDUCED LIVER-INJURY; ON-A-CHIP; CELL-CULTURE ANALOG; DRUG DISCOVERY; NAPHTHALENE TOXICITY; PHARMACOKINETIC PBPK; MECHANISTIC MODEL; REDUCE ATTRITION; PHARMACOLOGY; ORGANS;

D O I：

10.1039/c8lc00039e

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here, we first summarize why MPSs are needed in pharmaceutical development, and examine how MPS technologies can be utilized to improve preclinical efforts. We then provide the perspective that the full impact of MPS technologies will be realized only when robust approaches for in vitro-in vivo (MPS-to-human) translation are developed and utilized, and explain how the burgeoning field of quantitative systems pharmacology (QSP) can fill that need.

引用

页码：1831 / 1837

页数：7

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