Endoplasmic-reticulum-induced signal transduction and gene expression

被引:59
作者
Pahl, HL [1 ]
Baeuerle, PA [1 ]
机构
[1] TULARIK INC, San Francisco, CA 94080 USA
关键词
D O I
10.1016/S0962-8924(96)10050-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cells can respond to perturbations in endoplasmic reticulum (ER) function by activating two distinct signal-transduction pathways: one responds to unfolded proteins, the other to all overload of the organelle with membrane proteins. A third pathway is activated upon sterol depletion of cells and involves the cleavage and subsequent nuclear translocation of an ER membrane-bound transcription factor. Thus, three distinct pathways each activated by a different signal are currently known to project from the ER into the nucleus. This review summarizes the current understanding of these three pathways.
引用
收藏
页码:50 / 55
页数:6
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