The angiotensin II type 2 receptor: an enigma with multiple variations

被引:140
作者
Gallinat, S
Busche, S
Raizada, MK
Sumners, C
机构
[1] Univ Florida, Coll Med, Dept Physiol, Gainesville, FL 32610 USA
[2] Univ Florida, Inst Brain, Gainesville, FL 32610 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2000年 / 278卷 / 03期
关键词
seven transmembrane domain receptors; G protein; phosphatases; apoptosis; tissue regeneration;
D O I
10.1152/ajpendo.2000.278.3.E357
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since it was discovered ten years ago, the angiotensin II (ANG II) type 2 (AT(2)) receptor has been an enigma. This receptor binds ANG II with a high affinity but is not responsible for mediating any of the classical physiological actions of this peptide, all of which involve the ANG II type I (AT(1)) receptor. Furthermore, the AT(2) receptor exhibits dramatic differences in biochemical and functional properties and in patterns of expression compared with the AT(1) receptor. During the past decade, much information has been gathered about the AT(2) receptor, and the steadily increasing number of publications indicates a growing interest in this new and independent area of research. A number of studies suggest a role of AT(2) receptors in brain, renal, and cardiovascular functions and in the processes of apoptosis and tissue regeneration. Despite these advances, nothing stands out as the major singular function of these receptors. The study of AT(2) receptors has reached a crossroads, and innovative approaches must be considered so that unifying mechanisms as to the function of these unique receptors can be put forward. In this review we will discuss the advances that have been made in understanding the biology of the AT(2) receptor. Furthermore, we will consider how these discoveries, along with newer experimental approaches, may eventually lead to the elusive physiological and pathophysiological functions of these receptors.
引用
收藏
页码:E357 / E374
页数:18
相关论文
共 175 条
[1]   Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor [J].
Akishita, M ;
Yamada, H ;
Dzau, VJ ;
Horiuchi, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 261 (02) :345-349
[2]   Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth [J].
Akishita, M ;
Ito, M ;
Lehtonen, YA ;
Daviet, L ;
Dzau, VJ ;
Horiuchi, M .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (01) :63-71
[3]   EFFECTS OF ANGIOTENSIN-II AND ITS SELECTIVE ANTAGONISTS ON INFERIOR OLIVARY NEURONS [J].
AMBUHL, P ;
FELIX, D ;
IMBODEN, H ;
KHOSLA, MC ;
FERRARIO, CM .
REGULATORY PEPTIDES, 1992, 41 (01) :19-26
[4]   Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole [J].
Arima, S ;
Endo, Y ;
Yaoita, H ;
Omata, K ;
Ogawa, S ;
Tsunoda, K ;
Abe, M ;
Takeuchi, K ;
Abe, K ;
Ito, S .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (11) :2816-2823
[5]   Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts [J].
Bartunek, J ;
Weinberg, EO ;
Tajima, M ;
Rohrbach, S ;
Lorell, BH .
CIRCULATION, 1999, 99 (01) :22-25
[6]   Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase [J].
Bedecs, K ;
Elbaz, N ;
Sutren, M ;
Masson, M ;
Susini, C ;
Strosberg, AD ;
Nahmias, C .
BIOCHEMICAL JOURNAL, 1997, 325 :449-454
[7]  
BLEUEL A, 1995, J NEUROSCI, V15, P750
[8]   THE ANGIOTENSIN-AT2 RECEPTOR STIMULATES PROTEIN TYROSINE PHOSPHATASE-ACTIVITY AND MEDIATES INHIBITION OF PARTICULATE GUANYLATE-CYCLASE [J].
BOTTARI, SP ;
KING, IN ;
REICHLIN, S ;
DAHLSTROEM, I ;
LYDON, N ;
DEGASPARO, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (01) :206-211
[9]   The angiotensin AT(2) receptor is present in the human fetal adrenal gland throughout the second trimester of gestation [J].
Breault, L ;
Lehoux, JG ;
GalloPayet, N .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (11) :3914-3922
[10]   AGONISTIC AND ANTAGONISTIC PROPERTIES OF ANGIOTENSIN ANALOGS AT THE AT2-RECEPTOR IN PC12W CELLS [J].
BRECHLER, V ;
JONES, PW ;
LEVENS, NR ;
DEGASPARO, M ;
BOTTARI, SP .
REGULATORY PEPTIDES, 1993, 44 (02) :207-213