Incident type 2 diabetes mellitus in African American and white adults - The atherosclerosis risk in communities study

被引:394
作者
Brancati, FL
Kao, WHL
Folsom, AR
Watson, RL
Szklo, M
机构
[1] Johns Hopkins Univ, Dept Med, Baltimore, MD USA
[2] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA
[3] Univ Minnesota, Div Epidemiol, Minneapolis, MN 55455 USA
[4] Univ Mississippi, Med Ctr, Dept Prevent Med, Jackson, MS 39216 USA
[5] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2000年 / 283卷 / 17期
关键词
D O I
10.1001/jama.283.17.2253
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context Although the excess prevalence of type 2 diabetes mellitus in African Americans is well established, few studies have compared incident diabetes in African American and white persons. Objectives To compare risk of incident diabetes in African American vs white adults and to identify explanatory factors for racial disparities. Design Prospective cohort study using baseline data collected from 1986 to 1989 from the ongoing Atherosclerosis Risk in Communities (ARIC) Study, with 9 years of follow-up. Setting and Participants A total of 2646 African American and 9461 white adults aged 45 to 64 years without diabetes at baseline, sampled from 4 US communities. Main Outcome Measures Incident type 2 diabetes, ascertained by self-report of physician diagnosis, use of diabetes medications, or fasting glucose level of at least 7.0 mmol/L (126 mg/dL), compared among white and African American subjects and by presence of potentially modifiable risk factors. Results Diabetes incidence per 1000 person-years was about 2.4-fold greater in African American women (25.1 [95% confidence interval {CI}, 22.4-28.1] vs 10.4 [95% CI, 9.4-11.4]) and about 1.5-fold greater in men (23.4 [95% CI, 19.9-27.2] vs 15.9 [95% CI, 14.6-17.2]) than in their white counterparts (P<.001). Results from proportional hazards regression models indicated that racial differences in potentially modifiable risk factors, particularly adiposity, accounted for 47.8% of the excess risk in African American women but accounted for little excess risk in African American men. Compared with their white counterparts, African American men and women had higher blood pressures before diabetes onset (diastolic blood pressure difference=5.6 mm Hg in women and 8.4 mm Hg in men; P=.005). Conclusions Our data indicate that compared with their white counterparts, middle-aged African Americans are at greater risk of developing type 2 diabetes and have higher blood pressure prior to development of diabetes. In women, almost 50% of this excess risk might be related to potentially modifiable factors.
引用
收藏
页码:2253 / 2259
页数:7
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