Membrane simulations: bigger and better?

被引:159
作者
Forrest, LR [1 ]
Sansom, MSP [1 ]
机构
[1] Univ Oxford, Dept Biochem, Mol Biophys Lab, Oxford OX1 3QU, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0959-440X(00)00066-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular dynamics simulations of biological membranes have come of age. Simulations of pure lipid bilayers are extending our understanding of both optimal simulation procedures and the detailed structural dynamics of lipids in these systems. Simulation methods established using simple bilayer-embedded peptides are being extended to a wide range of membrane proteins and membrane protein models, and are beginning to reveal some of the complexities of membrane protein structural dynamics and their relationship to biological function.
引用
收藏
页码:174 / 181
页数:8
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