Macrophage inhibitory cytokine MIC-1 is upregulated by short-wavelength light in cultured normal human dermal fibroblasts

被引：18

作者：

Akiyama, Masashi ^{[1
,3
]}

Okano, Keiko ^{[1
]}

Fukada, Yoshitaka ^{[2
]}

Okano, Toshiyuki ^{[1
,2
,3
]}

机构：

[1] Waseda Univ, Grad Sch Adv Sci & Engn, Dept Elect Engn & Biosci, Shinjuku Ku, Tokyo 1628480, Japan

[2] Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Bunkyo Ku, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

FEBS LETTERS | 2009年 / 583卷 / 05期

关键词：

Near-UV light; Blue light; Dermal fibroblast; Microarray; MIC-1; TGF-BETA SUPERFAMILY; ULTRAVIOLET-RADIATION; MEMBER; EXPRESSION;

D O I：

10.1016/j.febslet.2009.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To better understand dermal response to visible light, we used DNA microarray analysis to search genes induced by blue or near-UV light in normal human dermal fibroblasts. Of about 12800 transcripts analyzed, near- UV light most prominently upregulated the transcript level of Mic-1, a gene encoding a TGF-beta superfamily protein. Quantitative RT-PCR and immunoblot analyses revealed that mRNA and protein levels of Mic-1 were upregulated by both short-wavelength light but not by green or red light. These results suggest that the human dermis is a site for macrophage inhibitory cytokine-1 (MIC-1) production and that visible light activates a dermal transcription cascade. Considering the role of MIC-1 in immune regulation and appetite control, photic MIC-1 regulation is of physiological importance. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：933 / 937

页数：5

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