The role of miR-150 in normal and malignant hematopoiesis

被引：100

作者：

He, Y. ^{[1
]}

Jiang, X. ^{[1
,2
]}

Chen, J. ^{[1
,2
]}

机构：

[1] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA

来源：

ONCOGENE | 2014年 / 33卷 / 30期

基金：

美国国家卫生研究院;

关键词：

miR-150; hematopoiesis; hematopoietic malignancies; expression profiles; gene regulation; target genes; B-CELL DEVELOPMENT; C-MYB; MICRORNA EXPRESSION; MEDIATED CONTROL; MLL; LEUKEMIA; IDENTIFICATION; LYMPHOMA; LINEAGE; DIFFERENTIATION;

D O I：

10.1038/onc.2013.346

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are a class of small non-coding RNAs that have been implicated to mediate gene regulation in virtually all important biological processes. Recently there is accumulating evidence showing that miR-150 has essential regulatory roles in both normal and malignant hematopoiesis and holds great potential as a therapeutic target in treating various types of hematopoietic malignancies. The purpose of this review is to summarize our current knowledge about the expression patterns, biological functions and regulatory mechanisms of miR-150 in normal and malignant hematopoiesis, and to highlight the important questions to be answered in this burgeoning field.

引用

页码：3887 / 3893

页数：7

共 67 条

[1] An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response
Adams, Brian D.
Guo, Shangqin
Bai, Haitao
Guo, Yanwen
Megyola, Cynthia M.
Cheng, Jijun
Heydari, Kartoosh
Xiao, Changchun
Reddy, E. Premkumar
Lu, Jun
[J]. CELL REPORTS, 2012, 2 (04): : 1048 - 1060
[2] Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth
Agirre, Xabier
Jimenez-Velasco, Antonio
San Jose-Eneriz, Edurne
Garate, Leire
Bandres, Eva
Cordeu, Lucia
Aparicio, Oscar
Saez, Borja
Navarro, German
Vilas-Zornoza, Amaia
Perez-Roger, Ignacio
Garcia-Foncillas, Jesus
Torres, Antonio
Heiniger, Anabel
Jose Calasanz, Maria
Fortes, Puri
Roman-Gomez, Jose
Prosper, Felipe
[J]. MOLECULAR CANCER RESEARCH, 2008, 6 (12) : 1830 - 1840
[3] [Anonymous], MOL CANC
[4] Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression
Barroga, Charlene F.
Pham, Hang
Kaushansky, Kenneth
[J]. EXPERIMENTAL HEMATOLOGY, 2008, 36 (12) : 1585 - 1592
[5] MicroRNAs: Target Recognition and Regulatory Functions
Bartel, David P.
[J]. CELL, 2009, 136 (02) : 215 - 233
[6] Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age
Behm, FG
Raimondi, SC
Frestedt, JL
Liu, Q
Crist, WM
Downing, JR
Rivera, GK
Kersey, JH
Pui, CH
[J]. BLOOD, 1996, 87 (07) : 2870 - 2877
[7] Critical functions for c-Myb at three checkpoints during thymocyte development
Bender, TP
Kremer, CS
Kraus, M
Buch, T
Rajewsky, K
[J]. NATURE IMMUNOLOGY, 2004, 5 (07) : 721 - 729
[8] miR-150 regulates the development of NK and iNKT cells
Bezman, Natalie A.
Chakraborty, Tirtha
Bender, Timothy
Lanier, Lewis L.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (13) : 2717 - 2731
[9] miR-150 Blocks MLL-AF9-Associated Leukemia through Oncogene Repression
Bousquet, Marina
Zhuang, Guoqing
Meng, Cong
Ying, Wei
Cheruku, Patali S.
Shie, Andrew T.
Wang, Stephanie
Ge, Guangtao
Wong, Piu
Wang, Gang
Safe, Stephen
Zhou, Beiyan
[J]. MOLECULAR CANCER RESEARCH, 2013, 11 (08) : 912 - 922
[10] Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis
Bruchova, Hana
Yoon, Donghoon
Agarwal, Archana M.
Mendell, Joshua
Prchal, Josef T.
[J]. EXPERIMENTAL HEMATOLOGY, 2007, 35 (11) : 1657 - 1667

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