Neurological manifestations of knockout mice with beta-galactosidase deficiency

被引：40

作者：

Matsuda, J ^{[1
]}

Suzuki, O ^{[1
]}

Oshima, A ^{[1
]}

Ogura, A ^{[1
]}

Naiki, M ^{[1
]}

Suzuki, Y ^{[1
]}

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BRAIN & DEVELOPMENT | 1997年 / 19卷 / 01期

关键词：

beta-galactosidase; gene targeting; G(M1)-gangliosidosis; animal model;

D O I：

10.1016/S0387-7604(96)00077-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We succeeded in producing the beta-galactosidase-deficient knockout mouse by gene targeting in embryonic stem cells. The mutant mice developed progressive spastic diplegia within a few months after birth, and died of emaciation at 7-10 months of age. This is an authentic murine model of human G(M1)-gangliosidosis, and is useful for studies of its pathogenesis and treatment. (C) 1997 Elsevier Science B.V.

引用

页码：19 / 20

页数：2

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