Asymmetric catalysis in the pharmaceutical industry

被引：123

作者：

Hawkins, JM ^{[1
]}

Watson, TJN ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Groton, CT 06340 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 25期

关键词：

asymmetric catalysis; chiral auxiliaries; freedom to operate; hydrogenation; industrial processes;

D O I：

10.1002/anie.200330072

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The best catalyst from a chemical perspective is not necessarily the best catalyst from an overall economic perspective. In competing approaches to candoxatril the most selective catalyst for the asymmetric hydrogenation (see scheme) was not the one ultimately chosen. The constraints of the pharmaceutical industry are discussed with regard to the application of asymmetric catalysis to the large-scale synthesis of drug candidates and commercial drugs.

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收藏

页码：3224 / 3228

页数：5

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