SPINE workshop on automated X-ray analysis: a progress report

被引：19

作者：

Bahar, M.

Ballard, C.

Cohen, S. X.

Cowtan, K. D.

Dodson, E. J.

Emsley, P.

Esnouf, R. M.

Keegan, R.

Lamzin, V.

Langer, G.

Levdikov, V.

Long, F.

Meier, C.

Muller, A.

Murshudov, G. N.

Perrakis, A.

Siebold, C.

Stein, N.

Turkenburg, M. G. W.

Vagin, A. A.

Winn, M.

Winter, G.

Wilson, K. S. ^{[1
]}

机构：

[1] Univ York, York Struct Biol Lab, Dept Chem, York YO10 5YW, N Yorkshire, England

[2] Wellcome Trust Ctr Human Genet, Div Struct Biol, Oxford OX3 7BN, England

[3] Wellcome Trust Ctr Human Genet, Oxford Prot Prod Facil, Oxford OX3 7BN, England

[4] CCLRC, Daresbury Lab, Warrington WA4 4AD, Cheshire, England

[5] Netherlands Canc Inst, Mol Carcinogenesis Dept, NL-1066 CX Amsterdam, Netherlands

[6] DESY, European Mol Biol Lab, D-22603 Hamburg, Germany

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2006年 / 62卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1107/S0907444906032197

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Structural Proteomics In Europe ( SPINE) consortium contained a workpackage to address the automated X- ray analysis of macromolecules. The aim of this workpackage was to increase the throughput of three- dimensional structures while maintaining the high quality of conventional analyses. SPINE was able to bring together developers of software with users from the partner laboratories. Here, the results of a workshop organized by the consortium to evaluate software developed in the member laboratories against a set of bacterial targets are described. The major emphasis was on molecular- replacement suites, where automation was most advanced. Data processing and analysis, use of experimental phases and model construction were also addressed, albeit at a lower level.

引用

页码：1170 / 1183

页数：14

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