The Nutrition, Aging, and Memory in Elders (NAME) Study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population

被引:47
作者
Scott, Tammy M.
Peter, Inga
Tucker, Katherine L.
Arsenault, Lisa
Bergethon, Peter
Bhadelia, Rafeeque
Buell, Jennifer
Collins, Lauren
Dashe, John F.
Griffith, John
Hibberd, Patricia
Leins, Drew
Liu, Timothy
Ordovas, Jose M.
Patz, Amuel
Price, Lori Lyn
Qiu, Wei Qiao
Sarnak, Mark
Selhub, Jacob
Smaldone, Lauren
Wagner, Carey
Wang, Lixia
Weiner, Daniel
Yee, Jacqueline
Rosenberg, Irwin
Folstein, Marshal
机构
[1] Tufts Univ, New England Med Ctr, Boston, MA 02111 USA
[2] Tufts Univ, Sch Med, Boston, MA 02111 USA
[3] Tufts Univ, Gerald J & Dorothy R Friedman Sch Nutr Sci & Poli, Boston, MA 02111 USA
[4] Jean Mayer USDA Human Nutr Res Ctr Aging HNRCA, Boston, MA USA
关键词
aging; cognition; elders; homocysteine; magnetic resonance imaging; micronutrients; nutrition;
D O I
10.1002/gps.1503
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background Micronutrient status can affect cognitive function in the elderly; however, there is much to learn about the precise effects. Understanding mediating factors by which micronutrient status affects cognitive function would contribute to elders' quality of life and their ability to remain in the home. Objectives The Nutrition, Aging, and Memory in Elders (NAME) Study is designed to advance the current level of knowledge by investigating potential mediating factors by which micronutrient status contributes to cognitive impairment and central nervous system abnormalities in the elderly. NAME targets homebound elders because they arc understudied and particularly at risk for poor nutritional status. Methods Subjects are community-based elders aged 60 and older, recruited through area Aging Services Access Points. The NAME core data include demographics; neuropsychological testing and activities of daily living measures; food frequency, health and behavioral questionnaires; anthropometrics, gene status; plasma micronutrients. homocysteine, and other blood determinants. A neurological examination, psychiatric examination, and brain MRI and volumetric measurements arc obtained from a sub-sample. Results Preliminary data from first 300 subjects are reported. These data show that the NAME protocol is feasible and that the enrolled subjects are racially diverse, at-risk, and had similar basic demographics to the population from which they were drawn. Conclusion The goal of the NAME study is to evaluate novel relationships between nutritional factors and cognitive impairment. These data may provide important information on potential new therapeutic strategies and supplementation standards for the elderly to maintain cognitivefunction and potentially reduce the public health costs of dementia. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码:519 / 528
页数:10
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