Use of sodium hetastarch (Hespan) solution for reduction of postoperative adhesion formation in rabbits

被引：3

作者：

Gist, RS

Lu, PY

Raj, HGM

Campbell, C

Elkins, TE

机构：

[1] MAYO CLIN & MAYO GRAD SCH MED, DEPT OBSTET & GYNECOL, DIV REPROD ENDOCRINOL, ROCHESTER, MN 55901 USA

[2] LOUISIANA STATE UNIV, MED CTR, SCH MED, DEPT OBSTET & GYNECOL, NEW ORLEANS, LA 70112 USA

来源：

JOURNAL OF INVESTIGATIVE SURGERY | 1996年 / 9卷 / 05期

关键词：

adhesions; hetastarch;

D O I：

10.3109/08941939609021278

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A study was conducted to determine the effect of sodium hydroxy ethyl starch (Hespan) on primary adhesion formation in a rabbit model. Hespan is a readily available volume expander. This was a randomized double-blinded animal model in which New Zealand white rabbits were subjected to midline celiotomy. Adhesions were created by abrasion in both uterine horns, adjacent bowel, and peritoneum. Necropsies were performed at the 2-week interval and adhesions were graded. Significant decreases in type II and type III adhesions (p = .032 and p = .020, respectively) were demonstrated in Hespan-treated animals. Sodium hetastarch appears to decrease significant adhesion formation in treated animals and may have a role as an adjunct for postsurgical prevention.

引用

页码：369 / 373

页数：5

共 14 条

[1]

[Anonymous], 1989, FERTIL STERIL, V51, P933

[2]

ELKINS TE, 1984, FERTIL STERIL, V41, P926

[3] THE INABILITY OF GORE-TEX SURGICAL MEMBRANE TO INHIBIT POST-RADICAL PELVIC-SURGERY ADHESIONS IN THE DOG-MODEL [J].