Regulation of cardiac hypertrophy by intracellular signalling pathways

被引：1524

作者：

Heineke, Joerg ^{[1
]}

Molkentin, Jeffery D. ^{[1
]}

机构：

[1] Univ Cincinnati, Childrens Hosp, Med Ctr, Div Mol Cardiovasc Biol,Dept Pediat, Cincinnati, OH 45229 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1983

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.

引用

页码：589 / 600

页数：12

共 143 条

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