Unique case of Helicobacter sp osteomyelitis in an immunocompetent child diagnosed by broad-range 16S PCR

被引：25

作者：

Harris, KA

Fidler, KJ

Hartley, JC

Vogt, J

Klein, NJ

Monsell, F

Novelli, VM

机构：

[1] Great Ormond St Hosp Children NHS Trust, Dept Microbiol, Camelia Botnar Labs, London WC1N 3JH, England

[2] Great Ormond St Hosp Children NHS Trust, Dept Infect Dis, London WC1N 3JH, England

[3] Great Ormond St Hosp Children NHS Trust, Dept Orthopaed, London WC1N 3JH, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2002年 / 40卷 / 08期

关键词：

D O I：

10.1128/JCM.40.8.3100-3103.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the first case of Helicobacter sp. osteomyelitis in an immunocompetent child. The infection was diagnosed by broad-range 16S PCR followed by sequencing of the resulting amplicon. All other microbiological investigations proved negative. This case highlights the importance of molecular methods in the diagnosis of unsuspected etiological agents and the potential role of Helicobacter sp. in human infection.

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页码：3100 / 3103

页数：4

相关论文

共 14 条

[1] Bacteremia and skin/bone infections in two patients with X-linked agammaglobulinemia caused by an unusual organism related to Flexispira/Helicobacter species [J].

Cuccherini, B ;

Chua, K ;

Gill, V ;

Weir, S ;

Wray, B ;

Stewart, D ;

Nelson, D ;

Fuss, I ;

Strober, W .

CLINICAL IMMUNOLOGY, 2000, 97 (02) :121-129

[2] 'Flexispira rappini' strains represent at least 10 Helicobacter taxa [J].

Dewhirst, FE ;

Fox, JG ;

Mendes, EN ;

Paster, BJ ;

Gates, CE ;

Kirkbride, CA ;

Eaton, KA .

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2000, 50 :1781-1787

[3]

Dewhirst FE, 2000, INT J SYST EVOL MICR, V50, P2231, DOI [10.1099/00207713-50-3-1401, 10.1099/00207713-50-3-1399]

[4] 16S ribosomal DNA sequence analysis of a large collection of environmental and clinical unidentifiable bacterial isolates [J].

Drancourt, M ;

Bollet, C ;

Carlioz, A ;

Martelin, R ;

Gayral, JP ;

Raoult, D .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (10) :3623-3630

[5] Identification of a unique Helicobacter species by 16S rRNA gene analysis in an abdominal abscess from a patient with X-linked hypogammaglobulinemia [J].

Han, SR ;

Schindel, C ;

Genitsariotis, R ;

Marker-Hermann, E ;

Bhakdi, S ;

Maeurer, MJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (07) :2740-2742

[6] Helicobacter cinaedi septic arthritis and bacteremia in an immunocompetent patient [J].

Lasry, S ;

Simon, J ;

Marais, A ;

Pouchot, J ;

Vinceneux, P ;

Boussougant, Y .

CLINICAL INFECTIOUS DISEASES, 2000, 31 (01) :201-202

[7] Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases [J].

Solnick, JV ;

Schauer, DB .

CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (01) :59-+

[8]

Suau A, 1999, APPL ENVIRON MICROB, V65, P4799

[9] Helicobacter rappini isolates from 2 homosexual men [J].

Tee, W ;

Jenney, A ;

McPhee, A ;

Mijch, A ;

Dyall-Smith, M .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (01) :E8-E11

[10] Flexispira rappini bacteremia in a child with pneumonia [J].

Tee, W ;

Leder, K ;

Karroum, E ;

Dyall-Smith, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (06) :1679-1682