tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the Arabidopsis circadian oscillator

被引：93

作者：

Panda, S

Poirier, GG

Kay, SA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

[3] CHU Laval, Res Ctr, Hlth & Environm Unit, Quebec City, PQ G1V 4G2, Canada

[4] Univ Laval, Quebec City, PQ G1V 4G2, Canada

来源：

DEVELOPMENTAL CELL | 2002年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1534-5807(02)00200-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In a genetic screen for altered circadian period length in Arabidopsis, we isolated a mutant with a long free-running period. The tej mutation acts independently of light quality and quantity. It affects clock-controlled transcription of genes in Arabidopsis and alters the timing of the photoperiod-dependent transition from vegetative growth to flowering. Map-based cloning of TEJ identified a poly(ADP-ribose) glycohydrolase (PARG). An inhibitor of poly(ADP-ribosyl)ation rescued the period phenotype of tej mutant and shortened the period length of wild-type plants. Posttranslational poly(ADP-ribosyl)ation of an oscillator component may contribute to setting the period length of the Arabidopsis central oscillator.

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页码：51 / 61

页数：11

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