ECT: Its Brain Enabling Effects A Review of Electroconvulsive Therapy-Induced Structural Brain Plasticity

被引：138

作者：

Bouckaert, Filip ^{[1
]}

Sienaert, Pascal ^{[1
]}

Obbels, Jasmien ^{[1
]}

Dols, Annemieke ^{[2
]}

Vandenbulcke, Mathieu ^{[1
]}

Stek, Max ^{[2
]}

Bolwig, Tom ^{[3
]}

机构：

[1] Univ Psychiat Ctr KU Leuven, Louvain, Belgium

[2] VUmc Amsterdam GGZinGeest, Amsterdam, Netherlands

[3] Inst Neuropsychiat, Copenhagen, Denmark

来源：

JOURNAL OF ECT | 2014年 / 30卷 / 02期

关键词：

electroconvulsive therapy; neuroplasticity; neurogenesis; angiogenesis; synaptogenesis; gliogenesis; hippocampus; BDNF; magnetic resonance imaging; NEUROTROPHIC FACTOR BDNF; ENDOTHELIAL-CELL PROLIFERATION; ADULT HIPPOCAMPAL NEUROGENESIS; NG2-EXPRESSING GLIAL-CELLS; DEPRESSED-PATIENTS; SEIZURES INCREASE; SYNAPTIC PROTEINS; RAT HIPPOCAMPUS; SERUM; VOLUME;

D O I：

10.1097/YCT.0000000000000129

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

Background: Since the past 2 decades, new evidence for brain plasticity has caused a shift in both preclinical and clinical ECT research from falsifying the "brain damage hypothesis" toward exploring ECT's enabling brain (neuro) plasticity effects. Methods: By reviewing the available animal and human literature, we examined the theory that seizure-induced structural changes are crucial for the therapeutic efficacy of ECT. Results: Both animal and human studies suggest electroconvulsive stimulation/electroconvulsive therapy (ECT)-related neuroplasticity (neurogenesis, synaptogenesis, angiogenesis, or gliogenesis). Conclusion: It remains unclear whether structural changes might explain the therapeutic efficacy and/or be related to the (transient) learning and memory impairment after ECT. Methods to assess in vivo brain plasticity of patients treated with ECT will be of particular importance for future longitudinal studies to give support to the currently available correlational data.

引用

页码：143 / 151

页数：9

共 121 条

[1]

Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways [J].