α-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective α Alkylation of α-Alkyl-α-alkynyl Esters

被引：46

作者：

Hashimoto, Takuya ^{[1
]}

Sakata, Kazuki ^{[1
]}

Maruoka, Keiji ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 27期

关键词：

alkylation; alkynes; asymmetric synthesis; phase-transfer catalysis; synthetic methods; ASYMMETRIC MANNICH REACTIONS; BETA-SULFONAMIDE ALCOHOL; AMINO-ACID DERIVATIVES; PROPARGYLIC ALCOHOLS; DIRECT-ADDITION; EFFICIENT SYNTHESIS; CONJUGATE ADDITION; TERMINAL ALKYNES; ALDOL REACTION; ALDEHYDES;

D O I：

10.1002/anie.200901977

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Going through the phases: The title reaction was found to proceed by an initial base-mediated isomerization to allenyl esters and subsequent phase transfer catalyzed alkylation at the α position of the ester (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5014 / 5017

页数：4

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