Three-dimensional conductive constructs for nerve regeneration

被引：44

作者：

George, Paul M. ^{[2
]}

Saigal, Rajiv ^{[2
]}

Lawlor, Michael W. ^{[3
,4
]}

Moore, Michael J. ^{[5
]}

LaVan, David A. ^{[6
]}

Marini, Robert P. ^{[7
]}

Selig, Martin ^{[3
]}

Makhni, Melvin ^{[4
]}

Burdick, Jason A. ^{[8
]}

Langer, Robert ^{[4
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp,Lab Biomat & Drug Delivery, Div Crit Care Med,Dept Anesthesiol, Boston, MA 02115 USA

[2] MIT, Div Hlth Sci & Technol, Cambridge, MA 02142 USA

[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02142 USA

[5] Tulane Univ, Dept Biomed Engn, New Orleans, LA 70118 USA

[6] Yale Univ, Dept Mech Engn, New Haven, CT 06511 USA

[7] MIT, Div Comparat Med, Cambridge, MA 02142 USA

[8] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2009年 / 91A卷 / 02期

关键词：

biocompatibility; electroactive polymer; nerve guide; nerve regeneration; polypyrrole; NEURITE OUTGROWTH; AXON REGENERATION; DRUG-DELIVERY; GROWTH-FACTOR; POLYMER; BIOCOMPATIBILITY; STIMULATION; COMPOSITE; SCAFFOLDS; BEHAVIOR;

D O I：

10.1002/jbm.a.32226

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The unique electrochemical properties of conductive polymers can be utilized to form stand-alone polymeric tubes and arrays of tubes that are suitable for guides to promote peripheral nerve regeneration. Noncomposite, polypyrrole (PPy) tubes ranging in inner diameter from 25 mu m to 1.6 mm as well as multichannel tubes were fabricated by electrodeposition. While oxidation of the pyrrole monomer causes growth of the film, brief Subsequent reduction allowed mechanical dissociation from the electrode mold, creating a stand-alone, conductive PPy tube. Conductive polymer nerve guides made in this manner were placed in transected rat sciatic nerves and shown to support nerve regeneration over an 8-week time period. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 519-527, 2009

引用

页码：519 / 527

页数：9

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