Cilia and Mucociliary Clearance

被引：441

作者：

Bustamante-Marin, Ximena M. ^{[1
]}

Ostrowski, Lawrence E. ^{[1
]}

机构：

[1] Univ N Carolina, Marsico Lung Inst, Cyst Fibrosis & Pulm Dis Res & Treatment Ctr, Chapel Hill, NC 27599 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2017年 / 9卷 / 04期

关键词：

AIRWAY EPITHELIAL-CELLS; CYSTIC-FIBROSIS; MUCUS CLEARANCE; CIGARETTE-SMOKE; BEAT FREQUENCY; TRACHEAL EPITHELIUM; MULTICILIATED CELLS; IN-VITRO; CHLAMYDOMONAS-REINHARDTII; PERICILIARY LIQUID;

D O I：

10.1101/cshperspect.a028241

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous layer out of the airways. In health this clearance mechanism is effective, but in patients with primary cilia dyskinesia (PCD) the cilia are abnormal, resulting in deficient MCC and chronic lung disease. This demonstrates the critical importance of the cilia for human health. In this review, we summarize the current knowledge of the components of the MCC apparatus, focusing on the role of cilia in MCC.

引用

页数：17

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