Cytokines and chemokines orchestrate atopic skin inflammation

被引：427

作者：

Homey, Bernhard

Steinhoff, Martin

Ruzicka, Thomas

Leung, Donald Y. M.

机构：

[1] Univ Dusseldorf, Dept Dermatol, D-40225 Dusseldorf, Germany

[2] Univ Hosp Munster, Dept Dermatol, Munster, Germany

[3] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80202 USA

[4] Univ Colorado, Natl Jewish Med & Res Ctr, Div Pediat Allergy Immunol, Denver, CO 80202 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2006年 / 118卷 / 01期

关键词：

atopic dermatitis; immunity; pruritus; lymphocyte; trafficking;

D O I：

10.1016/j.jaci.2006.03.047

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.

引用

收藏

页码：178 / 189

页数：12

相关论文

共 84 条

[1] A role for TSLP in the development of inflammation in an asthma model [J].

Al-Shami, A ;

Spolski, R ;

Kelly, J ;

Keane-Myers, A ;

Leonard, WJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (06) :829-839

[2] The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes [J].

Balabanian, K ;

Lagane, B ;

Infantino, S ;

Chow, KYC ;

Harriague, J ;

Moepps, B ;

Arenzana-Seisdedos, F ;

Thelen, M ;

Bachelerie, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35760-35766

[3] IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis [J].

Bilsborough, J ;

Leung, DYM ;

Maurer, M ;

Howell, M ;

Boguniewcz, M ;

Yao, L ;

Storey, H ;

LeCiel, C ;

Harder, B ;

Gross, JA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) :418-425

[4] The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria [J].

Bruna-Romero, O ;

Schmieg, J ;

Del Val, M ;

Buschle, M ;

Tsuji, M .

JOURNAL OF IMMUNOLOGY, 2003, 170 (06) :3195-3203

[5] Lymphocyte homing and homeostasis [J].

Butcher, EC ;

Picker, LJ .

SCIENCE, 1996, 272 (5258) :60-66

[6] Chemokines in tissue-specific and microenvironment-specific lymphocyte homing [J].

Campbell, JJ ;

Butcher, EC .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (03) :336-341

[7] Dendritic cell biology and regulation of dendritic cell trafficking by chemokines [J].

Caux, C ;

Ait-Yahia, S ;

Chemin, K ;

de Bouteiller, O ;

Dieu-Nosjean, MC ;

Homey, B ;

Massacrier, C ;

Vanbervliet, B ;

Zlotnik, A ;

Vicari, A .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2000, 22 (04) :345-369

[8] New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene-environment interactions [J].

Cork, Michael J. ;

Robinson, Darren A. ;

Vasilopoulos, Yiannis ;

Ferguson, Adam ;

Moustafa, Manar ;

MacGowan, Alice ;

Duff, Gordon W. ;

Ward, Simon J. ;

Tazi-Ahnini, Rachid .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :3-21

[9] Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites [J].

Dieu, MC ;

Vanbervliet, B ;

Vicari, A ;

Bridon, JM ;

Oldham, E ;

Aït-Yahia, S ;

Brière, F ;

Zlotnik, A ;

Lebecque, S ;

Caux, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (02) :373-386

[10] Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice [J].

Dillon, SR ;

Sprecher, C ;

Hammond, A ;

Bilsborough, J ;

Rosenfeld-Franklin, M ;

Presnell, SR ;

Haugen, HS ;

Maurer, M ;

Harder, B ;

Johnston, J ;

Bort, S ;

Mudri, S ;

Kuijper, JL ;

Bukowski, T ;

Shea, P ;

Dong, DL ;

Dasovich, M ;

Grant, FJ ;

Lockwood, L ;

Levin, SD ;

LeCiel, C ;

Waggie, K ;

Day, H ;

Topouzis, S ;

Kramer, J ;

Kuestner, R ;

Chen, Z ;

Foster, D ;

Parrish-Novak, J ;

Gross, JA .

NATURE IMMUNOLOGY, 2004, 5 (07) :752-760

← 1 2 3 4 5 6 7 8 9 →