Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products

被引：1022

作者：

Pardeike, Jana ^{[1
]}

Hommoss, Aiman ^{[1
]}

Mueller, Rainer H. ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Pharmaceut Technol Biopharmaceut & Nutricosm, D-12169 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 366卷 / 1-2期

关键词：

Solid lipid nanoparticles (SLN); Nanostructured lipid carriers (NLC); Dermal application; Cosmetic use; Pharmaceutical use; Dermal safety; SUB-VISIBLE MICROSPHERES; IN-VITRO RELEASE; TOPICAL DELIVERY; DRUG-DELIVERY; CYTOKINE PRODUCTION; TRANSDERMAL DELIVERY; OCCLUSIVE PROPERTIES; BEAGLE DOGS; PHYSICOCHEMICAL CHARACTERIZATION; PARELECTRIC SPECTROSCOPY;

D O I：

10.1016/j.ijpharm.2008.10.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solid lipid nanoparticles (SLN) are distinguishable from nanostructured lipid carriers (NLC) by the composition of the solid particle matrix. Both are an alternative carrier system to liposomes and emulsions. This review paper focuses on lipid nanoparticles for dermal application. Production of lipid nanoparticles and final products containing lipid nanoparticles is feasible by well-established production methods. SLN and NLC exhibit many features for dermal application of cosmetics and pharmaceutics, i.e. controlled release of actives, drug targeting, occlusion and associated with it penetration enhancement and increase of skin hydration. Due to the production of lipid nanoparticles from physiological and/or biodegradable lipids. this carrier system exhibits an excellent tolerability. The lipid nanoparticles are a "nanosafe" carrier. Furthermore, an overview of the cosmetic products currently oil the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：170 / 184

页数：15

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