Skp2 A dream target in the coming age of cancer therapy

被引：51

作者：

Chan, Chia-Hsin ^{[1
]}

Morrow, John Kenneth ^{[2
,3
]}

Zhang, Shuxing ^{[2
,3
]}

Lin, Hui-Kuan ^{[1
,3
,4
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[3] Univ Texas Houston, Grad Sch Biomed Sci Houston, Houston, TX USA

[4] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan

[5] Asia Univ, Dept Biotechnol, Taichung, Taiwan

来源：

CELL CYCLE | 2014年 / 13卷 / 05期

关键词：

cell cycle arrest; in silico modeling; senescence; cancer stem cells; cancer therapy; Skp2; inhibitor; glycolysis;

D O I：

10.4161/cc.27853

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

引用

页码：679 / 680

页数：2

共 8 条

[1]

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression [J].

Chan, Chia-Hsin ;

Morrow, John Kenneth ;

Li, Chien-Feng ;

Gao, Yuan ;

Jin, Guoxiang ;

Moten, Asad ;

Stagg, Loren J. ;

Ladbury, John E. ;

Cai, Zhen ;

Xu, Dazhi ;

Logothetis, Christopher J. ;

Hung, Mien-Chie ;

Zhang, Shuxing ;

Lin, Hui-Kuan .

CELL, 2013, 154 (03) :556-568

[2]

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis [J].

Chan, Chia-Hsin ;

Li, Chien-Feng ;

Yang, Wei-Lei ;

Gao, Yuan ;

Lee, Szu-Wei ;

Feng, Zizhen ;

Huang, Hsuan-Ying ;

Tsai, Kelvin K. C. ;

Flores, Leo G. ;

Shao, Yiping ;

Hazle, John D. ;

Yu, Dihua ;

Wei, Wenyi ;

Sarbassov, Dos ;

Hung, Mien-Chie ;

Nakayama, Keiichi I. ;

Lin, Hui-Kuan .

CELL, 2012, 149 (05) :1098-1111

[3]

Targeting the p27 E3 ligase SCFSkp2 results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy [J].

Chen, Qing ;

Xie, Weilin ;

Kuhn, Deborah J. ;

Voorhees, Peter M. ;

Lopez-Girona, Antonia ;

Mendy, Derek ;

Corral, Laura G. ;

Krenitsky, Veronique Plantevin ;

Xu, Weiming ;

Parseval, Laure Moutouh-de ;

Webb, David R. ;

Mercurio, Frank ;

Nakayama, Keiichi I. ;

Nakayama, Keiko ;

Orlowski, Robert Z. .

BLOOD, 2008, 111 (09) :4690-4699

[4]

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer [J].

Hershko, Dan D. .

CANCER, 2008, 112 (07) :1415-1424

[5]

Huang P.H., 2009, Sci. Signal, V2, pr

[6]

Morrow JK, 2012, CURR PHARM DESIGN, V18, P1255

[7]

Skp2 controls adipocyte proliferation during the development of obesity [J].

Sakai, Tamon ;

Sakaue, Hiroshi ;

Nakamura, Takehiro ;

Okada, Mitsuru ;

Matsuki, Yasushi ;

Watanabe, Eijiro ;

Hiramatsu, Ryuji ;

Nakayama, Keiko ;

Nakayama, Keiichi I. ;

Kasuga, Masato .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (03) :2038-2046

[8]

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation [J].

Wu, Lily ;

Grigoryan, Arsen V. ;

Li, Yunfeng ;

Hao, Bing ;

Pagano, Michele ;

Cardozo, Timothy J. .

CHEMISTRY & BIOLOGY, 2012, 19 (12) :1515-1524

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