Tissue distribution of surfactant proteins A and D in the mouse

被引：81

作者：

Akiyama, J

Hoffman, A

Brown, C

Allen, L

Edmondson, J

Poulain, F

Hawgood, S

机构：

[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94118 USA

[2] Univ Calif San Francisco, Inst Cardiovasc Res, San Francisco, CA 94118 USA

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2002年 / 50卷 / 07期

关键词：

surfactant proteins; collectins; innate immunity;

D O I：

10.1177/002215540205000713

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Surfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity. In this study we show that SP-A and SP-D mRNA can be detected in a significant number of non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only in the lung. The results suggest that SP-D participates in mucosal immunity throughout the body.

引用

收藏

页码：993 / 996

页数：4

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