Genetic dissection of gene regulation in multiple mouse tissues

被引：13

作者：

Cotsapas, Chris J.

Williams, Rohan B. H.

Pulvers, Jeremy N.

Nott, David J.

Chan, Eva K. F.

Cowley, Mark J.

Little, Peter F. R.

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Ramaciotti Ctr Gene Funct Anal, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Sch Math, Sydney, NSW 2052, Australia

来源：

MAMMALIAN GENOME | 2006年 / 17卷 / 06期

关键词：

D O I：

10.1007/s00335-005-0186-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of the influence of genetic variation on regulation of gene expression at a near-genome-wide level has become the focus of much recent interest. It is widely appreciated that many genes are expressed in a tissue-specific manner and that others are more ubiquitously expressed but relatively little is known about how genetic variation might influence these tissue patterns of gene expression. In this review we discuss what is known about the tissue specificity of the influence of genetic variation and review the challenges that we face in combining hugely parallel, microarray-based gene analysis with equally expensive genetic analysis. We conclude that the available data suggest that genetic variation is essentially tissue specific in its effects upon gene expression and this has important implications for experimental analysis.

引用

页码：490 / 495

页数：6

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