Tissue engineering strategies for promoting vascularized bone regeneration

被引：157

作者：

Almubarak, Sarah ^{[1
,4
,5
]}

Nethercott, Hubert ^{[1
,4
,5
]}

Freeberg, Marie ^{[1
,4
,5
]}

Beaudon, Caroline ^{[1
,4
,5
]}

Jha, Amit ^{[2
,3
]}

Jackson, Wesley ^{[2
,3
]}

Marcucio, Ralph ^{[1
]}

Miclau, Theodore ^{[1
]}

Healy, Kevin ^{[2
,3
]}

Bahney, Chelsea ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Orthopaed Surg, Orthopaed Trauma Inst, San Francisco, CA USA

[2] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA

[4] UCSF UCB Masters Translat Med Program, Berkeley, CA USA

[5] UCSF UCB Masters Translat Med Program, San Francisco, CA USA

来源：

BONE | 2016年 / 83卷

基金：

美国国家卫生研究院;

关键词：

Bone regeneration; Angiogenesis; Osteogenesis; Controlled release; Stem cells; Endochondral ossification; MESENCHYMAL STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; FIBROBLAST-GROWTH-FACTOR; MARROW STROMAL CELLS; UMBILICAL-CORD BLOOD; BB RHPDGF-BB; ADIPOSE-TISSUE; ENDOCHONDRAL OSSIFICATION; SONIC HEDGEHOG; IN-VIVO;

D O I：

10.1016/j.bone.2015.11.011

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This review focuses on current tissue engineering strategies for promoting vascularized bone regeneration. We review the role of angiogenic growth factors in promoting vascularized bone regeneration and discuss the different therapeutic strategies for controlled/sustained growth factor delivery. Next, we address the therapeutic uses of stem cells in vascularized bone regeneration. Specifically, this review addresses the concept of co-culture using osteogenic and vasculogenic stem cells, and how adipose derived stem cells compare to bone marrow derived mesenchymal stem cells in the promotion of angiogenesis. We conclude this review with a discussion of a novel approach to bone regeneration through a cartilage intermediate, and discuss why it has the potential to be more effective than traditional bone grafting methods. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：197 / 209

页数：13

共 213 条

[1]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2]

Avascular necrosis of the femoral head: Role of vascularized bone grafts [J].

Aldridge, J. Mack, III ;

Urbaniak, James R. .

ORTHOPEDIC CLINICS OF NORTH AMERICA, 2007, 38 (01) :13-+

[3]

Elasticity and adhesion force mapping reveals real-time clustering of growth factor receptors and associated changes in local cellular rheological properties [J].

Almqvist, N ;

Bhatia, R ;

Primbs, G ;

Desai, N ;

Banerjee, S ;

Lal, R .

BIOPHYSICAL JOURNAL, 2004, 86 (03) :1753-1762

[4]

Mesenchymal stem cells: immune evasive, not immune privileged [J].

Ankrum, James A. ;

Ong, Joon Faii ;

Karp, Jeffrey M. .

NATURE BIOTECHNOLOGY, 2014, 32 (03) :252-260

[5]

Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[6]

Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[7]

Endothelial Progenitor Cells Promote Fracture Healing in a Segmental Bone Defect Model [J].

Atesok, Kivanc ;

Li, Ru ;

Stewart, Duncan J. ;

Schemitsch, Emil H. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2010, 28 (08) :1007-1014

[8]

Endothelial cells and the IGF system [J].

Bach, Leon A. .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2015, 54 (01) :R1-R13

[9]

VISIBLE LIGHT PHOTOINITIATION OF MESENCHYMAL STEM CELL-LADEN BIORESPONSIVE HYDROGELS [J].

Bahney, C. S. ;

Lujan, T. J. ;

Hsu, C. W. ;

Bottlang, M. ;

West, J. L. ;

Johnstone, B. .

EUROPEAN CELLS & MATERIALS, 2011, 22 :43-55

[10]

The multifaceted role of the vasculature in endochondral fracture repair [J].

Bahney, Chelsea S. ;

Hu, Diane P. ;

Miclau, Theodore, III ;

Marcucio, Ralph S. .

FRONTIERS IN ENDOCRINOLOGY, 2015, 6

← 1 2 3 4 5 6 7 8 9 10 →