Applications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19

被引：45

作者：

Baptista, Abrahao Fontes ^{[1
,2
,3
,4
]}

Baltar, Adriana ^{[2
,5
]}

Okano, Alexandre Hideki ^{[1
,2
,3
,6
]}

Moreira, Alexandre ^{[7
]}

Campos, Ana Carolina Pinheiro ^{[8
]}

Fernandes, Ana Mercia ^{[9
]}

Brunoni, Andre Russowsky ^{[10
,11
]}

Badran, Bashar W. ^{[12
]}

Tanaka, Clarice ^{[2
,13
]}

de Andrade, Daniel Ciampi ^{[2
,9
]}

da Silva Machado, Daniel Gomes ^{[14
]}

Morya, Edgard ^{[15
]}

Trujillo, Eduardo ^{[1
,2
]}

Swami, Jaiti K. ^{[16
]}

Camprodon, Joan A. ^{[17
,18
]}

Monte-Silva, Katia ^{[2
,19
]}

Sa, Katia Nunes ^{[2
,20
,21
]}

Nunes, Isadora ^{[21
]}

Goulardins, Juliana Barbosa ^{[2
,4
,7
,22
]}

Bikson, Marom ^{[16
]}

Sudbrack-Oliveira, Pedro ^{[23
]}

de Carvalho, Priscila ^{[13
]}

Duarte-Moreira, Rafael Jardim ^{[1
,2
]}

Pagano, Rosana Lima ^{[8
]}

Shinjo, Samuel Katsuyuki ^{[24
]}

Zana, Yossi ^{[1
]}

机构：

[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, Brazil

[2] NAPeN Network Rede Nucleos Assistencia & Pesquisa, Sao Bernardo Do Campo, Brazil

[3] Univ Estadual Campinas, Brazilian Inst Neurosci & Neurotechnol, Ctr Pesquisa Invest & Difusao, Fundacao Amparo Pesquisa Estado Sao Paulo BRAINN, Campinas, Brazil

[4] Univ Sao Paulo, Lab Med Invest 54 LIM 54, Sao Paulo, Brazil

[5] Specialized Neuromodulat Ctr Neuromod, Recife, PE, Brazil

[6] Univ Estadual Londrina, Grad Program Phys Educ, Londrina, Parana, Brazil

[7] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil

[8] Hosp Sirio Libanes, Lab Neurosci, Sao Paulo, Brazil

[9] Univ Sao Paulo, Fac Med FMUSP, Dept Neurol, Ctr Dor,LIM62, Sao Paulo, Brazil

[10] Inst Nacl Biomarcadores Neuropsiquiatria, Lab Neurociencias LIM 27, Serv Interdisciplinar Neuromodulacao, Sao Paulo, Brazil

[11] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Psiquiatria, Sao Paulo, Brazil

[12] Med Univ South Carolina, Dept Psychiat, Charleston, SC 29425 USA

[13] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Inst Cent, Sao Paulo, Brazil

[14] Univ Fed Rio Grande do Norte, Grad Program Collect Hlth, Natal, RN, Brazil

[15] Santos Dumont Inst, Edmond & Lily Safra Int Neurosci Inst, Macaiba, Brazil

[16] CUNY, City Coll New York, Dept Biomed Engn, New York, NY 10031 USA

[17] Massachusetts Gen Hosp, Lab Neuropsychiat & Neuromodulat, Boston, MA 02114 USA

[18] Harvard Med Sch, Boston, MA 02115 USA

[19] Univ Fed Pernambuco, Appl Neurosci Lab, Recife, PE, Brazil

[20] Escola Bahiana Med & Saude Publ, Salvador, BA, Brazil

[21] Pontificia Univ Catolica Minas Gerais, Dept Physiotherapy, Betim, Brazil

[22] Univ Cruzeiro Sul UNICSUL, Sao Paulo, Brazil

[23] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, Brazil

[24] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo, Brazil

来源：

FRONTIERS IN NEUROLOGY | 2020年 / 11卷

基金：

巴西圣保罗研究基金会; 美国国家卫生研究院;

关键词：

coronavirus; COVID-19; non-invasive vagus nerve stimulation; taVNS; tDCS; TMS; neuromodulation; NIBS; DIRECT-CURRENT STIMULATION; VAGUS NERVE-STIMULATION; ACUTE RESPIRATORY SYNDROME; HEART-RATE-VARIABILITY; TRANSCRANIAL MAGNETIC STIMULATION; SYNDROME CORONAVIRUS INFECTION; NEURAL CELL-LINES; IMMUNE-SYSTEM; INFLAMMATORY MARKERS; PERSISTENT INFECTION;

D O I：

10.3389/fneur.2020.573718

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders. Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders. Results: Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways: (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway. Conclusion: COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19.

引用

页数：18

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