Mendelian and complex genetics of susceptibility and resistance to parasitic infections

被引：43

作者：

Campino, Susana

Kwiatkowski, Dominic

Dessein, Alain

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Univ Mediterranee, Fac Med, INSERM,UMR 399, Unit Genet & Immunol Parasit Dis, Marseille, France

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 06期

基金：

英国医学研究理事会;

关键词：

parasitic infections; malaria; schistosomiasis; leishmaniasis; genetics;

D O I：

10.1016/j.smim.2006.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Uncovering the complex genetic basis of susceptibility and resistance to parasitic infectious diseases is an enormous challenge. It probably involves many different host genes, interacting with multiple parasite genetic and environmental factors. Several genes of interest have been identified by family and association studies in humans and by using mouse models, but more robust epidemiological studies and functional data are needed to authenticate these findings. With new technologies and statistical tools for whole-genome association analysis, the next few years are likely to see acceleration in the rate of gene discovery, which has the potential to greatly assist drug and vaccine development. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：411 / 422

页数：12

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