Bone morphogenetic protein-7 and Gremlin: New emerging therapeutic targets for diabetic nephropathy

被引：42

作者：

Zhang, Yanling ^{[1
]}

Zhang, Qingxian ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 3, Dept Nephrol, Shijiazhuang 050051, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 01期

关键词：

Gremlin; Bone morphogenetic protein-7; Diabetic nephropathy; Therapy; GROWTH-FACTOR; HIGH GLUCOSE; CELL-PROLIFERATION; MESANGIAL CELLS; RENAL FIBROSIS; KIDNEY; EXPRESSION; INJURY; BMP7; FIBROGENESIS;

D O I：

10.1016/j.bbrc.2009.03.086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Specific therapies of diabetic nephropathy (DN) are not available, and Current treatment strategies are limited to management of blood glucose levels and control of hypertension. The re-activation of developmental programs in DN Suggests new potential therapeutic targets. Bone morphogenetic protein-7 (BMP-7) and its antagonist, Gremlin is revealed to be involved in renal development and diabetic nephropathy. This article reviews the changes of BMP-7 and Gremlin in diabetic kidney, the protective effects on diabetic nephropathy when targeting BMP-7 and Gremlin, and the possible mechanism. The reorganization of the re-activation of Gremlin and BMP-7 in diabetic kidney had shed light on the identification of novel therapeutic targets for DN. (C) 2009 Elsevier Inc. All rights reserved.

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页码：1 / 3

页数：3

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