Not just a sink: endosomes in control of signal transduction

被引:415
作者
Miaczynska, M [1 ]
Pelkmans, L [1 ]
Zerial, M [1 ]
机构
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
关键词
D O I
10.1016/j.ceb.2004.06.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Recent studies indicate that endocytic organelles can play a more active role in signal propagation and amplification than was recognised before. By deciphering the interplay between endocytosis and signalling, we will be able to gain a more sophisticated level of understanding of signal transduction mechanisms.
引用
收藏
页码:400 / 406
页数:7
相关论文
共 73 条
[1]   COMPARTMENTALIZED SIGNAL-TRANSDUCTION BY RECEPTOR TYROSINE KINASES [J].
BAASS, PC ;
DIGUGLIELMO, GM ;
AUTHIER, F ;
POSNER, BI ;
BERGERON, JJM .
TRENDS IN CELL BIOLOGY, 1995, 5 (12) :465-470
[2]   Adhesion-dependent cell mechanosensitivity [J].
Bershadsky, AD ;
Balaban, NQ ;
Geiger, B .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 :677-695
[3]   Ras pathway signaling on endomembranes [J].
Bivona, TG ;
Philips, MR .
CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :136-142
[4]   Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 [J].
Bivona, TG ;
Perez de Castro, I ;
Ahearn, IM ;
Grana, TM ;
Chiu, VK ;
Lockyer, PJ ;
Cullen, PJ ;
Pellicer, A ;
Cox, AD ;
Philips, MR .
NATURE, 2003, 424 (6949) :694-698
[5]   Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking [J].
Burke, P ;
Schooler, K ;
Wiley, HS .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (06) :1897-1910
[6]   Retrograde transport of neurotrophins: Fact and function [J].
Campenot, RB ;
MacInnis, BL .
JOURNAL OF NEUROBIOLOGY, 2004, 58 (02) :217-229
[7]   Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase [J].
Daaka, Y ;
Luttrell, LM ;
Ahn, S ;
Della Rocca, GJ ;
Ferguson, SSG ;
Caron, MG ;
Lefkowitz, RJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (02) :685-688
[8]   Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases [J].
Dale, LB ;
Seachrist, JL ;
Babwah, AV ;
Ferguson, SSG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :13110-13118
[9]   NGF signaling in sensory neurons: Evidence that early endosomes carry NGF retrograde signals [J].
Delcroix, JD ;
Valletta, JS ;
Wu, CB ;
Hunt, SJ ;
Kowal, AS ;
Mobley, WC .
NEURON, 2003, 39 (01) :69-84
[10]   Distinct endocytic pathways regulate TGF-β receptor signalling and turnover [J].
Di Guglielmo, GM ;
Le Roy, C ;
Goodfellow, AF ;
Wrana, JL .
NATURE CELL BIOLOGY, 2003, 5 (05) :410-421