Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetetraminepentaacetic acid

被引：37

作者：

Corson, DT ^{[1
]}

Meares, CF ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

BIOCONJUGATE CHEMISTRY | 2000年 / 11卷 / 02期

关键词：

D O I：

10.1021/bc990125x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed and optimized the synthesis of the title compound, eliminating all HPLC purifications prior to the final product. The yield (and scale) of the synthesis was increased from 19% (200 mg) to 75% (26 g).

引用

页码：292 / 299

页数：8

共 20 条

[1]

BORING CC, 1995, CA-CANCER J CLIN, V45, P12

[2]

BRECHBIEL WM, 1986, INORG CHEM, V25, P2272

[3]

BURCHELL J, 1987, CANCER RES, V47, P5476

[4] ANTIBODY-GUIDED IRRADIATION OF ADVANCED OVARIAN-CANCER WITH INTRAPERITONEALLY ADMINISTERED RADIOLABELED MONOCLONAL-ANTIBODIES [J].

EPENETOS, AA ;

MUNRO, AJ ;

STEWART, S ;

RAMPLING, R ;

LAMBERT, HE ;

MCKENZIE, CG ;

SOUTTER, P ;

RAHEMTULLA, A ;

HOOKER, G ;

SIVOLAPENKO, GB ;

SNOOK, D ;

COURTENAYLUCK, N ;

DHOKIA, B ;

KRAUSZ, T ;

TAYLORPAPADIMITRIOU, J ;

DURBIN, H ;

BODMER, WF .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (12) :1890-1899

[5] CLONING OF PARTIAL CDNA-ENCODING DIFFERENTIATION AND TUMOR-ASSOCIATED MUCIN GLYCOPROTEINS EXPRESSED BY HUMAN MAMMARY EPITHELIUM [J].

GENDLER, SJ ;

BURCHELL, JM ;

DUHIG, T ;

LAMPORT, D ;

WHITE, R ;

PARKER, M ;

TAYLORPAPADIMITRIOU, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (17) :6060-6064

[6] ADJUVANT THERAPY OF OVARIAN-CANCER WITH RADIOACTIVE MONOCLONAL-ANTIBODY [J].

HIRD, V ;

MARAVEYAS, A ;

SNOOK, D ;

DHOKIA, B ;

SOUTTER, WP ;

MEARES, C ;

STEWART, JSW ;

MASON, P ;

LAMBERT, HE ;

EPENETOS, AA .

BRITISH JOURNAL OF CANCER, 1993, 68 (02) :403-406

[7]

MARAVEYAS A, 1994, CANCER, V73, P1067, DOI 10.1002/1097-0142(19940201)73:3+<1067::AID-CNCR2820731346>3.0.CO

[8]

2-#

[9]

MARSONI S, 1990, BRIT J CANCER, V62, P21

[10] CONJUGATION OF ANTIBODIES WITH BIFUNCTIONAL CHELATING-AGENTS - ISOTHIOCYANATE AND BROMOACETAMIDE REAGENTS, METHODS OF ANALYSIS, AND SUBSEQUENT ADDITION OF METAL-IONS [J].

MEARES, CF ;

MCCALL, MJ ;

REARDAN, DT ;

GOODWIN, DA ;

DIAMANTI, CI ;

MCTIGUE, M .

ANALYTICAL BIOCHEMISTRY, 1984, 142 (01) :68-78

← 1 2 →