Identification of four novel dinucleotide repeat polymorphisms in the TNF-α and TNF-β genes

被引：3

作者：

Khani-Hanjani, A

Hoar, D

Horsman, D

Keown, P

机构：

[1] Vancouver Gen Hosp, Immunol Lab, Dept Lab Med & Pathol, Vancouver, BC V5Z 1M9, Canada

[2] Vancouver Gen Hosp, Dept Med, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

来源：

HUMAN IMMUNOLOGY | 2000年 / 61卷 / 05期

关键词：

TNF-alpha; TNF-beta; microsatellite polymorphism; HLA;

D O I：

10.1016/S0198-8859(99)00188-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five polymorphic regions (a to e) have been recognized within the TNF gene region. These polymorphisms appear to be of biological importance as individual alleles have been associated with higher production of TNF and/or an increased risk of rheumatoid arthritis or diabetes mellitus. We report here the detection of four new alleles designated a14 (122 bp), b8 (131 bp), b9 (132 bp), and d0 (122 bp) in patients with rheumatoid arthritis and normal controls from the Pacific Northwest. This increases to 39 the number of alleles now recognized at: these loci. Human Immunology 61, 511-512 (2000). (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.

引用

页码：511 / 512

页数：2

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