A hormonal association between estrogen metabolism and proliferative thyroid disease

被引：18

作者：

Chan, EK

Sepkovic, DW

Bowne, HJY

Yu, GP

Schantz, SP

机构：

[1] New York Eye & Ear Infirm, New York Med Coll, Dept Otolaryngol Head & Neck Surg, New York, NY 10003 USA

[2] Hackensack Univ, Med Ctr, Hackensack, NJ 07601 USA

[3] New York Eye & Ear Infirm, Dept Otolaryngol Head & Neck Surg, New York, NY USA

[4] New York Eye & Ear Infirm, St Vincents Hosp Manhattan, New York, NY USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2006年 / 134卷 / 06期

关键词：

D O I：

10.1016/j.otohns.2006.01.020

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE: To illustrate a relationship between proliferative thyroid disease and estrogen metabolism through the analysis of urinary estrogen metabolites. STUDY DESIGN AND SETTING: Case-control study of 49 subjects with proliferative thyroid disorders and matching them to 49 controls. Urinary estrogen metabolite ratios were obtained, measuring 2-hydroxyestrone, an anti-proliferative metabolite, to 16 alpha-hydroxyestrone, a proliferative metabolite. The patients were stratified into low (0 to 1.00), medium (1.01 to 2.00), or high (> 2.00) groups according to their estrogen metabolite ratio. RESULTS: Fifty-one percent (25 of 49) of the cases had a low 2/16 ratio compared to 31% (15 of 49) in the control group while 20% (10 of 49) of the control group had a high 2/16 ratio as compared to 8% (4 of 49) in the case group (P value < 0.05). CONCLUSIONS: increased 16 alpha-hydroxyestrone activity compared to 2-hydroxyestrone activity appears to be associated with proliferative thyroid disease. SIGNIFICANCE: Further study of estrogen metabolites in relation to proliferative thyroid disease is warranted and may lead to implications for new treatment modalities for proliferative thyroid disease.

引用

页码：893 / 900

页数：8

共 21 条

[1] Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines [J].