Adverse event associated with methionine loading test - A case report

被引：21

作者：

Cottington, EM

LaMantia, C

Stabler, SP

Allen, RH

Tangerman, A

Wagner, C

Zeisel, SH

Mudd, SH

机构：

[1] NIMH, Mol Biol Lab, DIRP, Bethesda, MD 20892 USA

[2] Case Western Reserve Univ, Cleveland, OH 44106 USA

[3] Univ Colorado, Hlth Sci Ctr, Div Hematol, Denver, CO USA

[4] Univ Med Ctr Nijmegen, Div Gastroenterol & Hepatol, Nijmegen, Netherlands

[5] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

[6] Dept Vet Affairs Med Ctr, Nashville, TN 37212 USA

[7] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA

[8] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2002年 / 22卷 / 06期

关键词：

methionine load elevation; cerebral death;

D O I：

10.1161/01.ATV.0000020400.25088.A7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The death of a control subject after an oral load of methionine for a study of the possible relationship between homocysteine and Alzheimer's disease is reported. The subject developed postload plasma concentrations of methionine far beyond those reported previously in humans given the usual oral loading dose of methionine (100 mg/kg body wt). Her preload plasma metabolite values rule out known genetic diseases that might predispose one to unusually high methionine concentrations. The most likely explanation for these events is that the subject received a substantial overdose of methionine. The possibility that extremely high methionine concentrations may lead to severe cerebral effects is discussed, and it is recommended that any move to increase the sensitivity of the usual methionine loading test by increasing the dose of methionine either not be undertaken or be taken only with extreme care.

引用

页码：1046 / 1050

页数：5

共 41 条

[1] SERUM BETAINE, N,N-DIMETHYLGLYCINE AND N-METHYLGLYCINE LEVELS IN PATIENTS WITH COBALAMIN AND FOLATE-DEFICIENCY AND RELATED INBORN-ERRORS OF METABOLISM [J].