Stereloselective synthesis of D-desosamine and related glycals via tungsten-catalyzed cycloisomerization alkynol

被引：65

作者：

Davidson, MH ^{[1
]}

McDonald, FE ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 10期

关键词：

D O I：

10.1021/ol049630m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective synthesis Of D-desosamine diacetate ester (iii, R = Ac) was achieved from the glycal (ii) generated by tungsten carbonyl-catalyzed cycloisomerization of the corresponding amino-alkynol (i). A wide variety of N-substituents (R, R') are compatible with the cycloisomerization, provided that at least one R or R' is an acyl derivative.

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页码：1601 / 1603

页数：3

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