Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking

被引：59

作者：

Hanada, Kentaro ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Biochem & Cell Biol, Shinjuku Ku, Tokyo 1628640, Japan

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2006年 / 286卷 / 1-2期

关键词：

ceramide; CERT; endoplasmic reticulum; Golgi apparatus; lipid trafficking; sphingomyelin;

D O I：

10.1007/s11010-005-9044-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Synthesis and sorting of lipids are essential events for membrane biogenesis and its homeostasis. Ceramide is synthesised at the endoplasmic reticulum (ER), and translocated to the Golgi compartment for conversion to sphingomyelin (SM). We have recently identified a key factor (named CERT) for ceramide trafficking. In this short review, I summarise recent advances in molecular mechanisms of intracellular transport of ceramide, focusing on our genetic and biochemical approaches to this issue.

引用

页码：23 / 31

页数：9

共 46 条

[1] The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases [J].

Ardail, D ;

Popa, I ;

Bodennec, J ;

Louisot, P ;

Schmitt, D ;

Portoukalian, J .

BIOCHEMICAL JOURNAL, 2003, 371 (03) :1013-1019

[2] SEMI-INTACT CELLS PERMEABLE TO MACROMOLECULES - USE IN RECONSTITUTION OF PROTEIN-TRANSPORT FROM THE ENDOPLASMIC-RETICULUM TO THE GOLGI-COMPLEX [J].

BECKERS, CJM ;

KELLER, DS ;

BALCH, WE .

CELL, 1987, 50 (04) :523-534

[3] Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities [J].

Dowler, S ;

Currie, RA ;

Campbell, DG ;

Deak, M ;

Kular, G ;

Downes, CP ;

Alessi, DR .

BIOCHEMICAL JOURNAL, 2000, 351 (01) :19-31

[4] Reduction of sphingomyelin level without accumulation of ceramide iu Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-β-cyclodextrin [J].

Fukasawa, M ;

Nishijima, M ;

Itabe, H ;

Takano, T ;

Hanada, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (44) :34028-34034

[5] Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells [J].

Fukasawa, M ;

Nishijima, M ;

Hanada, K .

JOURNAL OF CELL BIOLOGY, 1999, 144 (04) :673-685

[6] Reconstitution of ATP- and cytosol-dependent transport of de Novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells [J].

Funakoshi, T ;

Yasuda, S ;

Fukasawa, M ;

Nishijima, M ;

Hanada, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :29938-29945

[7] DETERMINATION OF THE INTRACELLULAR SITES AND TOPOLOGY OF GLUCOSYLCERAMIDE SYNTHESIS IN RAT-LIVER [J].

FUTERMAN, AH ;

PAGANO, RE .

BIOCHEMICAL JOURNAL, 1991, 280 :295-302

[8]

FUTERMAN AH, 1990, J BIOL CHEM, V265, P8650

[9] Molecular machinery for non-vesicular trafficking of ceramide [J].

Hanada, K ;

Kumagai, K ;

Yasuda, S ;

Miura, Y ;

Kawano, M ;

Fukasawa, M ;

Nishijima, M .

NATURE, 2003, 426 (6968) :803-809

[10] Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin - Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase [J].

Hanada, K ;

Hara, T ;

Fukasawa, M ;

Yamaji, A ;

Umeda, M ;

Nishijima, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) :33787-33794

← 1 2 3 4 5 →