Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

被引：68

作者：

Yatsunami, J ^{[1
]}

Tsuruta, N ^{[1
]}

Ogata, K ^{[1
]}

Wakamatsu, K ^{[1
]}

Takayama, K ^{[1
]}

Kawasaki, M ^{[1
]}

Nakanishi, Y ^{[1
]}

Hara, N ^{[1
]}

Hayashi, S ^{[1
]}

机构：

[1] SAGA MED SCH,DEPT INTERNAL MED,SAGA 849,JAPAN

来源：

CANCER LETTERS | 1997年 / 120卷 / 01期

关键词：

lung cancer; interleukin-8; angiogenesis; immunohistochemistry;

D O I：

10.1016/S0304-3835(97)00296-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-X staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-g producing cell lines in a mouse model. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：101 / 108

页数：8

共 24 条

[1] INDUCTION OF VASCULAR ENDOTHELIAL TUBULAR MORPHOGENESIS BY HUMAN GLIOMA-CELLS - A MODEL SYSTEM FOR TUMOR ANGIOGENESIS [J].