Improved preparation of A-ring phosphine oxides for the synthesis of vitamin D analogs

被引：5

作者：

Daniewski, AR ^{[1
]}

Garofalo, LN ^{[1
]}

Kabat, MM ^{[1
]}

机构：

[1] Hoffmann La Roche Inc, Preclin Res & Dev, Nonclin Dev, Chem Synth Proc Res, Nutley, NJ 07110 USA

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 19期

关键词：

D O I：

10.1081/SCC-120012994

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, high yielding, two-step process for the preparation of A-ring phospine oxides from allyl alcohols, useful for the synthesis of vitamin D analog, is described, in which triphosgene and diphenylphosphine oxide arc used for chlorination and subsequent substitution reactions, respectively.

引用

页码：3031 / 3039

页数：9

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